Research Areas

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Research topics and selected publications

1. Meerwein Arylations

1.1 Carboamination reactions


Base-induced radical carboamination of non-activated alkenes with aryldiazonium salts


S. Kindt, K. Wicht, M. R. Heinrich, Org. Lett. 2015, 17, 6122-6125


1.2 Carbooxygenation reactions



Manganese(IV)-mediated hydroperoxyarylation of alkenes with arylhydrazines and dioxygen from air

S. Kindt, H. Jasch, M. R. Heinrich, Chem. Eur. J. 2014, 20, 6251–6255


1.3 Carbofluorination reactions

Intramolecular radical carbofluorination of non-activated alkenes


S. Kindt, M. R. Heinrich, Chem. Eur. J. 2014, 20, 15344-15348


2. Gomberg-Bachmann-reactions (radical aryl-aryl coupling reactions)

The Gomberg-Bachmann reaction for the arylation of anilines with aryl diazotates


G. Pratsch, T. Wallaschkowski, M. R. Heinrich, Chem. Eur. J. 2012, 18. 11555-11559


Oxidative radical arylation of anilines with arylhadrazines and dioxygen from air


J. Hofmann, H. Jasch, M. R. Heinrich, J. Org. Chem. 201479, 2314–2320


3. Phenylazocarboxylates

Fast and efficient 18F-labelling by [18F]Fluorophenylazocarboxylic esters


S. Fehler, S. Maschauer, S. Höfling, A. Bartuschat, N. Tschammmer, H. Hübner, P. Gmeiner, O. Prante, M. R. Heinrich, Chem. Eur. J. 2014, 20, 370-375


The trapping of phenyldiazene in cycloaddition reactions


S. K. Fehler, G. Pratsch, M. R. Heinrich, Angew. Chem. 2014, 126, 11543–11548, Angew. Chem. Int. Ed. 2014, 53, 11361-11365


Zinc-mediated allylation and benzylation of phenylazocarboxylic esters



R. Lasch, M. R. Heinrich, J. Org. Chem. 2015, 80, 10412-10420


4. Conformational fixation of amides

Switching and conformational fixation of amides through proximate positive charges



A. L. Bartuschat, K. Wicht, M. R. Heinrich, Angew. Chem. Int. Ed. 201554, 10294–10298


5. Combination of denitrification and synthesis 

Fixation and recycling of nitrogen monoxide through carbonitrosation reactions



C. de Salas, M. R. Heinrich, Green Chem. 2014, 16, 2982-2987


Oxidative nitration of styrenes for the recycling of low-concentrated nitrogen dioxide in air


D. Hofmann, C. de Salas,  M. R. Heinrich, ChemSusChem 2015, 8, 3167-3175


6. Medicinal chemistry

Synthesis and biological evaluation of biphenyl amides that modulate the US28 receptor


A. Kralj, E. Kurt, N. Tschammer, M. R. Heinrich, ChemMedChem 2014, 9, 151-168


2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor - H1/H4-receptor selectivity



S. G. Hammer, S. Gobleder, F. Naporra, H.-J. Wittmann, S. Elz, M. R. Heinrich, A. Strasser, Bioorg. Med. Chem. Lett. 201626, 292-300