M.Sc. Ana Kralj

Ph.D. Thesis

  • Synthesis and Biological Evaluation of New Ligands fort he G-Protein Coupled US28 Receptor of Human Cytomegalovirus

Curriculum Vitae

  • 2010-2013 Ph.D. in Organic / Pharmaceutical Chemistry with Prof. Dr. Markus Heinrich, Friedrich-Alexander-Universität Erlangen-Nürnberg
  • 2009 Quality Assurance, Lek Pharmaceuticals d.d./ Sandoz d.d., Ljubljana, Slovenia 
  • 2003-2009 Faculty of Pharmacy, Ljubljana, Slovenia (Diploma); Graduation thesis in the workgroup of Prof. Dr. Janez Kerč (Lek Pharmaceuticals d.d./ Sandoz d.d., Ljubljana, Slovenia): "Self-assembly of polyelectrolytes with a model protein ovalbumine"   
  • 1999-2003 Gymnasium Kranj, Slovenia 
  • 1991-1999 Primary school, Kranj, Slovenia
  • 1984 born in Kranj, Slovenia


Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and beta-aminoisobutyrate metabolism in healthy volunteers
A. Kittel, F. Müller, J. König, M. Mieth, S. Bode-Böger, A. Kralj, M. R. Heinrich, M. F. Fromm, R. Maas, PLOS ONE 2014, 9, e88544
DOI: 10.1371/journal.pone.0088544
Synthesis and biological evaluation of biphenyl amides that modulate the US28 receptor
A. Kralj, E. Kurt, N. Tschammer, M. R. Heinrich, ChemMedChem 2014, 9, 151-168
DOI: 10.1002/cmdc.201300369
Development of flavonoid-based inverse agonists of the key signaling receptor US28 of Human Cytomegalovirus
A. Kralj, M.-T. Nguyen, N. Tschammer, N. Ocampo, Q. Gesiotto, M. R. Heinrich, O. Phanstiel,  J. Med. Chem. 2013, 56, 5019-5032
DOI: 10.1021/jm4003457
Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus
A. Kralj, A. Wetzel, S. Mahmoudian, T. Stamminger, N. Tschammer, M. R. Heinrich, Bioorg. Med. Chem. Lett. 2011, 21, 5446-5450
DOI: 10.1016/j.bmcl.2011.06.120