Eichler Laboratory- Selected Publications

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Peptide Paratope Mimics of the broadly neutralizing HIV-1 Antibody b12.
Haußner, C.; Damm, D.; Nirschl, S.; Rohrhofer, A.; Schmidt, B.; Eichler, J.
ChemBiochem, accepted.
DOI: 10.1002/cbic.201600621

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.
Lind, A.; Backert, S.; Hoffmann, R.; Eichler, J.; Yamaoka, Y.; Perez-Perez, G.I.; Torres, J.; Sticht, H.; Tegtmeyer, N.
BMC Microbiology 2016, 16:201.
DOI: 10.1186/s12866-016-0820-6

Synthetic Peptides as Protein Mimics.
Groß, A.; Hashimoto, C.; Sticht, H.;Eichler, J.
Front.Bioeng.Biotechnol. 2016, 3:211.
DOI: 10.3389/fbioe.2015.00211

A monosaccharide residue is sufficient to maintain mouse and human IgG subclass activity and directs IgG effector functions to cellular Fc-receptors.
Kao, D.; Danzer, H.; Collin, M.; Groß, A.; Eichler, J.; Stambuk, J.; Lauc, G.; Lux, A.; Nimmerjahn, J.
Cell Reports 2015, 13, 2376-2385.
DOI: 10.1016/j.celrep.2015.11.027

Virtual screening of a milk peptide database for the identification of food-derived antimicrobial peptides.
Liu, Y.; Eichler, J.;Pischetsrieder, M.
Mol.Nutr.Food Res. 2015, 59, 2243-2254.
DOI: 10.1002/mnfr.201500182

Synthetic peptides mimicking the binding site of human acetylcholinesterase for its inhibitor fasciculin 2.
Kafurke, U.; Erijman, A.; Aizner, Y.; Shifman, J.M.; Eichler, J.
J.Peptide Sci. 2015, 21, 723-730.
DOI: 10.1002/psc.2797

Turning peptide ligands into small-molecule inhibitors of protein-protein interactions.
Hashimoto, C.; Eichler, J.
ChemBioChem 2015, 16, 1855-1856.
DOI: 10.1002/cbic.201500298

Ligand selectivity of a synthetic CXCR4 mimic.
Groß, A.; Brox, R.; Damm, D.; Tschammer, N.; Schmidt, B.; Eichler, J.
Bioorg.Med.Chem. 2015, 23, 4050-4055.
DOI: 10.1016/j.bmc.2015.03.003

Enhancement and induction of HIV-1 infection through an assembled peptide derived from envelope glycoprotein gp120.
Groß, A.; Rödel, K.; Kneidl, B.; Donhauser, N.; Mössl, M.; Lump, E.; Münch, J.; Schmidt, B.; Eichler, J.
ChemBioChem 2015, 16, 446-454.
DOI: 10.1002/cbic.201402545

Influence of Nonenzymatic Posttranslational Modifications on Constitution, Oligomerization and Receptor Binding of S100A12.
Augner, K.; Eichler, J.; Utz, W.; Pischetsrieder, M.
PLoS One 2014.
DOI: 10.1371/journal.pone.0113418

Versatile trivalent C3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer.
Berthelmann, A.; Lach, J.; Gräwert M.A.; Groll, M.; Eichler
J. Org.Biomol.Chem. 2014, 12(16), 2606-2614.
DOI: 10.1039/C3OB42251H

Mimicking protein-protein interactions through peptide-peptide interactions: HIV-1 gp120 and CXCR4.
Groß, A.; Möbius, K.; Haußner, C.; Donhauser, N.; Schmidt, B.; Eichler, J.
Frontiers in Immunology 2013.
DOI: 10.3389/fimmu.2013.00257

Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3).
Diestel, U.; Resch, M.; Meinhardt, K.; Weiler, S.; Hellmann, T.V.; Mueller, T.D.; Nickel, J.; Eichler, J.; Muller, Y.A.
PLoS One 2013, 8(6), e67214.
DOI: 10.1371/journal.pone.0067214

HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop.
Eissmann, K.; Mueller, S.; Sticht, H.; Jung, S.; Zou, P.; Jiang, S.; Groß, A.; Eichler, J.; Fleckenstein, B.; Reil, H.
PLOSone 2013, 8 (1), e54452.
DOI: 10.1371/journal.pone.0054452

Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120.
Meier, J.; Kassler, K.; Sticht, H.; Eichler, J.
Beilstein J.Org.Chem.2012 8, 1858-1866, 2012.
DOI: 10.3762/bjoc.8.214

Exploring Converse Molecular Mechanisms of anti-HIV-1 Antibodies Using a Synthetic CXCR4 Mimic.
Haußner, C.; Möbius, K.; Eichler, J.
Bioorg.Med.Chem.Lett.
2012, 22, 6099-6102.
DOI: 10.1016/j.bmcl.2012.08.035

The nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting
through classical importin α binding.

Webel, R.; Solbak, S.M.Ø.; Held, C.; Milbradt, C.; Groß, A.; Eichler, J.; Wittenberg, T.; Jardin, C.; Sticht, H.; Fossen, T.; Marschall, M.
J.Gen.Virol. 2012, 93, 1756-1768.
DOI: 10.1099/vir.0.040592-0

A Functionally Selective Synthetic Mimic of the HIV-1 Coreceptor CXCR4.
Möbius, K.; Dürr, R.; Haußner, C.; Dietrich, U.; Eichler, J.
Chem.Eur.J. 2012, 18, 8292-8295.
DOI: 10.1002/chem.201200111

Structural basis for Species Selectivity in the HIV-1 gp120 - CD4 interaction: Restoring affinity to gp120 in murine CD4 mimetic peptides.
Kassler, K.; Meier, J.; Eichler, J.; Sticht, H.
Adv.Bioinformatics 2011, Volume 2011, Article ID 736593.
DOI: 10.1155/2011/736593

Differential Downregulation of ACE2 by Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63.
Glowacka, I.; Bertram, S.; Herzog, P.; Pfefferle, S.; Steffen, I.; Muench, M.O.; Simmons, G.; Hofmann, H.; Kuri, T.; Weber, F.; Eichler, J.;
Drosten, C.; Pöhlmann, S.
J.Virol. 2010, 84, 1198-1205.
DOI: 10.1128/JVI.01248-09

Peptide ligands selected with CD4-induced epitopes on native dualtropic HIV-1 envelope proteinsmimic extracellular coreceptor domains and
bind to HIV-1 gp120 independently of coreceptor usage.

Dervillez, X.; Klaukien, V.; Dürr, R.; Koch, J.; Kreutz, A.; Haarmann, T.; Stoll, M.; Lee, D.; Carlomagno, T.; Schnierle, B.; Möbius, K.; Königs, C.;
Griesinger, C.; Dietrich, U.
J.Virol. 2010, 84, 10131-10138.
DOI: 10.1128/JVI.00165-10

HIV-derived peptide mimics.
Möbius, K.; Eichler, J.
Drug Discovery Today: Technologies 2009, 6 (1-4), e19-e25.
DOI: 10.1016/j.ddtec.2009.09.001

The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, suggests explanations for
paralog-specific binding to Ena/VASP homology (EVH) 1 domains.

Link, N.M.; Hunke, C.; Mueller, J.W.; Eichler, J.; Bayer, P.
Biol.Chem. 2009 390 (5-6),417-426.
DOI: 10.1515/BC.2009.045

Peptides as protein binding site mimetics.
Eichler, J.
Curr.Opin.Chem.Biol. 2008 12, 707-713.
DOI: 10.1016/j.cbpa.2008.09.023

Synthetic Mimetics of the gp130 Binding Site for Viral Interleukin-6 as Inhibitors of the vIL-6 – gp130 Interaction.
Sudarman, E.; Bollati-Fogolin, M.; Hafner, M.; Müller, W.; Scheller, J.; Rose-John, S.; Eichler, J.
Chem.Biol.Drug Des. 2008, 71, 494-500.
DOI: 10.1111/j.1747-0285.2008.00649.x

Structural/Functional Mimicry of the Binding Site of hYAP-WW Domain for Proline-Rich Ligands.
Strijowski, U.; Hirsch, T.; Quintilla, A.; Wenzel, W.; Eichler, J.
Int.J.Peptide Res.Therap. 2007, 13(1-2),245-250.
DOI: 10.1007/s10989-006-9074-8

Synthetic Mimetics of the CD4 Binding Site of HIV-1 gp120 for the Design of Immunogens.
Franke, R.; Hirsch, T.; Overwin, H.; Eichler, J.
Angew.Chem. 2007 119(8), 1275-1277 (Int.Ed. 46(8), 1253-1255).
DOI: 10.1002/anie.200603274

ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.
Taussig, M.J.; Stoevesandt, O.; Borrebaeck, C.A.K.; Bradbury, A.R.; Cahill, D.; Cambillau, C.; de Daruvar, A.; Dübel, S.; Eichler, J.; Frank, R.;
Gibson, T.J.; Gloriam, D.; Gold, T.; Herberg, F.W.; Hermjakob, H.; Hoheisel, J.D.; Joos, T.O.; Kallioniemi. O.; Koegll, M.; Konthur, Z.; Korn, B.;
Kremmer, E.; Krobitsch, S.; Landegren,U.; van der Maarel, S.; McCafferty, J.; Muyldermans, S.; Nygren, P.A.; Palcy, S.; Plückthun, A.; Polic, B.;
Przybylski, M.;Saviranta, P.; Sawyer, A.; Sherman, D.J.; Skerra, A.; Templin, M.; Ueffing, M.; Uhlén, M.
Nature Methods 2007 4, 13-17.
DOI:10.1038/nmeth0107-13

A Rationally Designed Synthetic Mimic of the Discontinuous CD4 Binding Site of HIV-1 gp120.
Franke, R.; Hirsch, T.; Eichler, J.
J.Recept.Sig.Transd. 2006, 26, 453-460.
DOI: 10.1080/10799890600923179

Abrogation of vIL-6 induced signaling by intracellular retention and neutralization of vIL-6 with an anti vIL-6 single-chain antibody selected by phage display.
Kovaleva, M.; Bußmeyer, I.; Rabe1, B.; Sudarman, E.; Eichler, J.; Conrad, U.; Rose-John, S.; Scheller, J.
J.Virolol. 2006, 80, 8510-8520.
DOI:10.1128/JVI.00420-06

Structure-Based Synthetic Mimicry of Discontinuous Protein Binding Sites: Inhibitors of the Interaction of Mena EVH1 Domain with Proline-Rich Ligands.
Hunke, C.; Hirsch, T.; Eichler, J.
ChemBioChem 2006, 7(8), 1258-1264.
DOI: 10.1002/cbic.200500465

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells.
Stuhlmann-Laisz, C.; Lang, S.; Chalaris, A.;  Sudarman, E.; Eichler, J.; Klingmüller, U.; Samuel, M.;  Ernst, M.; Rose-John, S.; Scheller, J.
Molecular Biology of the Cell 2006, 17, 2986-2995.
DOI: 10.1091/mbc.E05-12-1129

Peptide ligation through click chemistry for the generation of assembled and scaffolded peptides.
Franke, R.; Doll, C.; Eichler, J.
Tetrahedron Lett. 2005, 46(26), 4479-4482.
DOI:10.1016/j.tetlet.2005.04.107

Synthetic Peptide Arrays and Peptide Combinatorial Libraries for the Exploration of Protein-Protein Interactions and the Design of Protein Inhibitors.
Eichler, J.
Comb.Chem.High Throughput Screen. 2005,8(2), 135-143.
DOI: 10.2174/1386207053258497

Post-Genomic Chemistry.
Varfolomeyev, S.; Efremenko, E.; Beletskaya, I.; Bertini, I.; Blackburn, G.M.; Bogdanov, A.; Cunin, R.; Eichler, J.; Galaev, I.; Gladyshev, V.;
O’Hagan, D.; Haertle, T.; Jarv, J.; Karyakin, A.; Kurochkin, I.; Mikolajczyk, M.; Poroikov, V.; Sakharov, I.; Spener, F.; Voyer, N.; Wild, J.
Pure Appl.Chem. 2005, 77(9): 1641-1654.
DOI: 10.1351/pac200577091641

Loops on Loops: Generation of Complex Scaffolded Peptides Presenting Multiple Cyclic Fragments.
Franke, R.; Doll, C.; Wray V.; Eichler, J.
Org.Biomol.Chem. 2004, 2(19): 2847-2851.
DOI: 10.1039/b403720k

Development of a monoclonal antibody-based immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition.
Scheller, J.; Kovaleva, M.; Rabe, B.; Eichler, J.; Kallen, K.J.; Rose-John, S.
J.Immunol.Methods 2004, 291(1-2): 93-100, 2004.
DOI: 10.1016/j.jim.2004.05.002

Rational and Random Strategies for the Mimicry of Discontinuous Protein Binding Sites.
                                              
Eichler, J.
Protein Peptide Lett. 2004, 11(4): 281-290, 2004.
DOI: 10.2174/0929866043406931